Publications

  1. Aronheim, A., Zandi, E., Hennemann, H., Elledge, S.J., and Karin, M. “Isolation of an AP1 repressor by a novel method for detecting protein-protein interactions” Mol. Cell. Biol. 17, 3094-3102 (1997). Aronheim MCB 199
  2. Aronheim, A. “Improved Efficiency Sos Recruitment System: Expression of the mammalian GAP reduces isolation of Ras GTPase false positives” Nuc. Acids Res. 25, 3373-3374 (1997). Aronheim-NAR 1997
  3. Yu, X., Wu, L.C., Bowcock, A.M., Aronheim, A., and Baer, R. “The Carboxy-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression” J. Biol. Chem. 273, 25388-25392 (1998). Yu et al. 1998
  4. Aronheim, A*., Broder, Y.C., Cohen, A., Fritsch, A., Belisle, B. and Abo, A*. “Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton” Curr. Biol. 8, 1125-1128 (1998). Aronheim et al Curr Biol 1998
  5. Broder, Y.C*. Katz, S*., and Aronheim, A. “The Ras recruitment system, a novel approach to the study protein-protein interactions” Curr. Biol. 8, 1121-1124 (1998). Broder et al Curr biol 98
  6. Isakoff, S.J., Cardozo, T., Andreev, J., Li, Z., Ferguson, K.M., Abagyan, R., Lemmon, M.A., Aronheim, A., and Skolnik, E.Y. “Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast” EMBO J. 17, 5374-5387 (1998). Isakoff et al EMBO-1998
  7. Maroun, M. and Aronheim, A. “A novel in vivo assay for the analysis of protein-protein interaction” Nuc. Acids Res. 27, E4 (1999). Maroun and Aronheim-NAR-1999
  8. Hubsman, M., Yudkovsky, G. and Aronheim A. “A novel approach for the identification of protein-protein interaction with integral membrane proteins” Nuc. Acids Res. 29, E18 (2001). Hubsman-NAR-2000
  9. Piu, F., Aronheim, A., Katz, S. and Karin, M. “AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation” Mol. Cell. Biol. 21, 3012-3024 (2001).
  10. Barak, O., Aronheim, A. and Shaul, Y. “HBV X protein targets HIV Tat-binding protein-1” Virology 283, 110-120 (2001). Piu-MCB-2000
  11. Katz, S., Heinrich, R. and Aronheim A. “The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase” FEBS Letters 506, 196-200 (2001). Katz-FEBS-2001
  12. Wardell, S.E., Boonnyaratanakornkit, V., Adelman, J.S., Aronheim, A. and Edwards, D.P. “Jun dimerization protein-2 (JDP-2) functions as a progesterone receptor N-terminal domain coactivator” Mol. Cell. Biol. 22, 5451-5466 (2002). Wardell-MCB-2002
  13. Holmberg, C., Katz, S., Lerdrup, M., Herdegen, T., Jäättelä, M., Aronheim, A*. and Kallunki, T.* “A novel specific role for I-kappa B kinase complex-associated protein in cytosolic stress signaling” J. Biological Chemistry 277, 31918-31928 (2002). Holemberg-JBC-2002
  14.  Baron, D., Assaraf, Y.G*., Cohen, N. and Aronheim, A*. “Lack of plasma membrane targeting of a G172D mutant thiamine transporter derived from Rogers syndrome family” Molecular Medicine 8, 462-474 (2002). Baron-MolMedicine-2002
  15.     Ostrovsky, O., Bengal, E*. and Aronheim, A*. “Induction of terminal differentiation by the c-Jun dimerization protein, JDP2, in C2 myoblasts and rhabdomyosarcoma cells” J. Biological Chemistry 277, 40043-40054 (2002). Ostrovsky-JBC-2002
  16.   Katz, S. and Aronheim, A. “Differential targeting of the stress MAPKs to the c-Jun dimerization protein 2” Biochemical J. 368, 939-945 (2002). Katz-BJ-2002
  17.   Ogawa, H., Ueda, T., Aoyama, T., Aronheim, A., Nagata, S. and Fukunaga R. “A SW12/SNF2-type ATPase/helicase protein, mDomino, interacts with myeloid zinc finger protein 2A (MZF-2A) to regulate its transcriptional activity” Genes to Cells 8, 325-339 (2003). Ogawa-GenesCells-2003
  18.     Rothem, L., Aronheim, A. and Assaraf, Y.G. “Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells” J. Biological Chemistry 278, 8935-8941 (2003). Rothem-JBC-2003
  19. Blazek E., Wasmer S., Kruse U, Aronheim A., Aoki M, Vogt P.K. “Partial oncogenic transformation of chicken embryo fibroblasts by Jun dimerization protein 2, a negative regulator of TRE- and CRE-dependent transcription” Oncogene 22, 2151-2159 (2003). Blazek-Oncogene-2003
  20. Conticello S. G., Kowalsman N. D., Jacobsen C., Yudkovsky G., Sato K., Elazar Z., Petersen C. M., Aronheim A. and Fainzilber M. “The pro-domain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors” J. Biological Chemistry 278, 26311-26314 (2003). Conticello-JBC-2003
  21. Baron, D., Assaraf, Y.G., Drori, S. and Aronheim, A. “Disruption of transport activity in a D93H mutant thiamine transporter 1, from a Rogers Syndrome family” Eur J. Biochem. 270, 4469-4477 (2003). Baron-EJB-2003
  22. Heinrich, R., Livne, E., Ben-Izhak, O. and Aronheim, A. “The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene” J. Biol. Chem. 279, 5708-5715 (2004). Heinrich-JBC-2004
  23. Frankel, P., Aronheim, A., Kavanagh, E., Balda, M.S., Matter, K., Bunney, T.D. and Marshall, C.J. “RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity” EMBO J. 24, 54-62 (2005). Frankel-EMBO-2005
  24. Kehat, I., Heinrich, R., Ben-Izhak, O., Miyazaki, H., Gutkind J.S., and Aronheim, A. “Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation” Cardiovascular Res. 70, 543-554 (2006). Kehat-CVR-2006
  25. Weisz Hubsman, M., Volinsky, N., Manser, E., Yablonski, D*. and Aronheim, A*. “Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp” Biochemical J. 404, 487-497 (2007). Hubsman-BJ-2007
  26. Weidenfeld-Baranboim, K., Bitton-Worms, K. and Aronheim, A. “TRE-dependent transcription activation by JDP2-CHOP10 association” Nucleic Acids Research 36, 3608-3619 (2008). Baranboim-Worms-NAR-2008
  27. Weidenfeld-Baranboim, K., Hasin, T., Darlyuk, I., Heinrich, R., Elhanani, O., Pan, J., Yokoyama KK.  and Aronheim A. “The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3” Nucleic Acids Research, 37, 2194-2203 (2009). Baranboim-NAR-2009
  28. Wasserman, T.*, Katsenelson, K.*, Daniliuc, S.*, Hasin, T., Choder, M. and Aronheim A. “A novel JNK binding protein WDR62 is recruited to stress granules and mediates a non-classical JNK activation” Mol. Biol. Cell 21, 117-130 (2010). Wasserman-KC-MBC-2010sup
  29. Bitton-Worms, K., Pikarsky, E. and Aronheim, A. “The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice” Molecular Cancer 9, 54 (2010). Worms-Bittom-MC-2010
  30.  Hasin, T*., Elhanani, O*., Abassi, Z., Hai, T. and Aronheim, A. “Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium” Basic Research in Cardiology 106, 175-187 (2011). Hasin-Elhanani-BRC-2011
  31.  Weidenfeld-Baranboim, K*., Koren, L*. and Aronheim, A. “JDP2 phosphorylation on threonine 148 by the c-Jun N-terminal kinase targets its proteosomal degradation” Biochemical J. 436, 661-669 (2011). Baranboim and Koren BJ 2011
  32.  Cohen-Katsenelson K*., Wasserman, T*., Khateb, S., Whitmarsh, A.J. and  Aronheim, A. “Docking interactions of the JNK scaffold protein WDR62” Biochemical J. 439, 381-390 (2011). KC-Wasserman BJ 2011
  33. Darlyuk-Saadon, I., Weidenfeld-Baranboim, K., Yokoyama, K.K., Hai, T. and Aronheim, A. “The bZIP repressor proteins, c-Jun Dimerization Protein 2 and Activating Transcription Factor 3, recruit multiple HDAC members to the ATF3 promoter” BBA Gene Regulatory Mechanisms 1819, 1142-1153 (2012). Saadon-Darlyuk BBA 2012
  34. Cohen-Katsenelson, K*., Wasserman, T*., Darlyuk-Saadon, I*, Rabner, A., Glaser, F., and Aronheim, A. “Identification and analysis of a novel dimerization domain shared by various members of JNK scaffold proteins” J. Biol. Chem. 288, 7294-7304 (2013). KC-TW-IS-dimerization JBC 2013
  35. Hill, C., Wurfel, A., Heger, J., Meyering, B., Schluter, K.-D, Weber, M., Ferdinandy, P., Aronheim, A., Schulz, R., and Euler, G. “Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction” Cardiovascular Research 99, 121-128 2013; doi: 10.1093/cvr/cvt094. Hill CVR 2013
  36. Koren, L., Elhanani, O., Kehat, I., Hai, T. and Aronheim, A. “Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy” PLoS ONE 8(7): e68396. doi:10.1371/journal.pone.0068396 (2013). Koren-PLoS-2013
  37. Koren, L., Alishekevitz, D., Elhanani, O., Nevelsky, A., Hai, T., Shaked, Y., and Aronheim, A. “ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling” International J. of Cardiology 198, 232-240 (2015). Koren et al 2015
  38. Koren, L., Shaked, Y. and Aronheim, A. “ATF3: A promoter or inhibitor of cardiac maladaptive remodeling” Response letter to the editor: International J. of Cardiology 201, 692 (2015).  Koren IJC et al 2015B
  39. Barbarov, Y., Timaner, M., Alishekevitz, D., Hai, T., Yokoyama, K.K., Shaked, Y*. and Aronheim A.* “Host JDP2 expression in the bone marrow contributes to metastatic spread” Oncotarget DOI 10.18632/oncotarget.5648 (2015). Barbarov Yelena 2015
  40. Hadad, M., Aviram, S. Darlyuk-Saadon, I., Cohen-Katsenelson, K., Whitmarsh A.J. and Aronheim, A. “The association of the JNK scaffold protein, WDR62, with the Mixed Lineage Kinase 3, MLK3, controls its kinase activity” MAP Kinase Journal DOI: http://dx.doi.org/10.4081/mk.2015.5307 (2015). Hadad MAPK J 2015
  41. Koren, L., Barash, U., Zohar, Y., Karin, N. and Aronheim, A. “The cardiac maladaptive ATF3-dependent cross-talk between cardiomyocytes and macrophages is mediated by the IFNg-CXCL10-CXCR3 axis” International Journal of Cardiology, 228, 394-400 (2016). Koren et al 2016
  42. Gutter-Kapon, L., Alishekevitz, D., Shaked, Y., Li, J.P., Aronheim, A., Ilan, N., and Vlodavsky I. “Heparanase is required for activation and function of macrophages” Proc. Nat. Acad. Sci. USA. 113, E7808-E7817 (2016) Gutter-Kapon-2016
  43. Kalfon, R., Koren, L., Aviram, S., Hai, T., and Aronheim, A. “ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance” Cardiovascular Research 113, 134-146 (2017).  Kalfon-CVR-2017 Editorial letter on Kalfon et al Editorial Kalfon et al
  44. Davidi, S., Fremder, E., Kan, T., Raviv, Z., Timaner, M., Karin, N., Hershkovitz, D., Arohneim, A., and Shaked, Y. “The antiangiogenic role of the pro-inflammatory cytokine interleukin-31” Oncotarget (2017). Davidi Oncotarget 2017